Erik,
If I ever am fortunate enough to have the time/ability to do doctoral work...this will be my topic.
Through nearly 20 years of drawing maps for-hire, if there is one thing I have become convinced about beyond a shadow of a doubt, it is that different people's brains are wired to navigate space and decipher wayfinding materials differently. Not just the obvious things, such as blindness, color-blindness, language, et al. I'm talking how our brains take visual bits of information and turn it into an understanding of where we are, and/or where we want to go.
We've worked with about 500 clients over the years. I've asked many clients the question about which makes "more sense" to them: planimetric map designs...where North is almost always on top, and a scale for distances is almost always present, versus bird's eye/oblique/pictorial maps...where direction and distances isn't as important as accurately depicting the details of various buildings/landmarks, getting color right, etc.
Almost to an equal split, about 50% of individuals have said that they need North on top and planimetric map designs to make the most sense of their surroundings, while the other 50% say they need accurate building facades and "three-dimensional" landmarks in order to orient themselves most-effectively.
Planimetric - Tend to be more men than women. Tend to be more "left-brained" in their career pursuits.
Bird's Eye/Oblique/Pictorial - Tend to be more women than men. Tend to be more "right-brained" in their career pursuits.
Now...look at who makes maps...as well as what has happened to cartography over the past several decades. The shift from hand-drawn work and more "bird's eye/oblique" depictions to GIS and data, with a program compiling the "base" which one then uses a "brewer" to choose their colors, fonts, et al. Map-making has shifted from more of an artistic/creative pursuit (right-brained) to one that is more left-brained at its core. Map-making has (at least from my attendance at several NACIS conferences and what I see here in CartoTalk) also remained heavily-dominated by men.
So...what happened? How did we go from the "art" of map design to "cartography" and a more left-brained pursuit?! And how effectively can all the left-brained men truly understand how "wayfinding" is wired into a right-brained individual (man or, even more difficult, woman)? To complicate matters even further, why is it left-brained men who have the privilege and responsibility of determining the "right" or "proper" way to navigate space?
It gets at the issue for web/GUI designers known as user-centered design. If a bunch of left-brained men are teaching the next generation of left-brained men the "right" way to understand wayfinding and spatial relationships, what about the (at least) fifty percent of the rest of them/us? How is it right for us to draw maps that make sense to us...then force others who get far less benefit/understanding from said maps to change and adapt to our way of understanding the world around us?
I think it is a similar issue to being left-handed (which I am) vs. right-handed...only in the case of navigating space, there are FAR more than seven percent of individuals who don't see things the way "we" see it. I still remember playing little league baseball back in the 1970s. How they gave every kid who wanted to play a glove...only they didn't have any left-handed gloves, so I had to spend the entire Summer learning to catch and throw at second base playing right-handed. How when they taught us how to bat, they taught me how to hit as a right-handed player. How they forced me to conform to the majority...even though that was *not* how I personally interacted with the world of baseball. Heck, even fast-forward to today! In 2011, when you buy a child's scissors in the store, try cutting a piece of paper with the scissors in your left hand. Doesn't work very well. Put that scissors in your right hand? Works great!
I think the danger in cartography, as with any industry, is making judgments of "right" and "wrong" ways to intepret and understand information being presented...versus really taking the time to understand how end-users make sense of what we create.
How does design make a difference?! Well, we all can either be the little league coach asking kids if they are left-handed or right-handed at the beginning of Summer (before our glove purchases are made)....OR we can be the little league coach who just orders 15-20 right-handed gloves and calls it a day.

Sorry for the novel. Does that count as partial credit toward a dissertation?! Ha!