Nice map, good color scheme. I agree about the fonts, not my typical style but it works here and guide maps often make use of non conventional fonts better than a reference or street map does.
I agree about the road symbols, the shadow effect makes them pop to the top of the visual hierarchy when I would guess that the legend items are of more importance?
I like that you included exit numbers but I usually see these as squares not circles. The numbered circle makes me think they are a reference to a note in the text somewhere.
Similar comment for fire stations. Because both fire stations and POIs are the same small colored circles they appear related on the map but are completely different features. I'd look at using another symbol for fire, maybe just a red square.
Most of the lines on the map are various thicknesses of black, you could break that up a little by choosing a gray for smaller roads, or a color for the hwy. I m might also look at making the Appalachian Trail another color.
Without a town symbol or urban-area polygon the town names are hard for me to place.
I agree on the comment made for the small locator, it looks good but the yellow section seems out of place with the other area fills. See if you can find a color of about the same saturation as the others.
There is a bit of an "island effect" going on because the roads stop at the edge of the district boarders. You might look at continuing the road lines in a very light gray to the edge of the page to help anchor the map and reference it to the other district maps you will be doing.
All that said this is essentially good to go as is and looks very nice.
Edited to add: you may also want to add a highlight outline to the district in the small locator map to emphasize which of the locations is being shown in the main map.
GIS Reference and Instruction Specialist, Stanford Geospatial Center.