If your workflow for small scale maps includes <GIS to your favorite drawing program>, I recommend creating an editing cover grid to aid in your QAQC.
An editing vector grid is a simple vector grid layer to overlay on your map and can easily be created in GIS. Add this layer before you export the GIS map to your drawing program for finishing.
I have created one that I use, composed of 40 sq mile blocks, with urban areas composed of 20 sq mile blocks. See the example screen shot below...